phytic acid mitigates motor asymmetry in male rat with unilateral 6-hydroxydopamine striatal lesion

background and objective: parkinson's disease (pd) is a movement disorder with debilitating symptoms. available treatments for pd mainly include its symptomatic relief with no prevention of its progression. due to the iron-chelating and antioxidant effect of phytic acid (pa), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of pd in rat. materials and methods: unilateral intrastriatal 6-ohda-lesioned rats were daily pretreated with pa p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. apomorphine-induced rotations were counted at 1st week post-surgery. results: a significant contralateral rotational behavior was observed in 6-ohda-lesioned rats (pconclusion: these findings imply that pre-lesion pa treatment could attenuate motor asymmetry in experimental model of pd and this may be of benefit in lessening motor derangements in afflicted patients.